Gold Carbon Core Shell Nanoparticles (Au/C, 99.9%, APS: 80-100nm, Metal Core/Metal Shell)

Gold Carbon Core-Shell Nanoparticles

Applications:

Biosensing and Diagnostics:

Optical Biosensing: The plasmonic properties of the gold core enhance the optical signals from the carbon shell, allowing for highly sensitive biosensing applications. Au-C core-shell nanoparticles can be functionalized with antibodies or aptamers to detect specific biomarkers in disease diagnostics, such as cancer or infectious diseases. The LSPR effect can be used to detect changes in the plasmonic resonance upon binding to target molecules, enabling real-time sensing and early detection of diseases.

Fluorescent Biosensing: The carbon shell can also be functionalized with fluorescent labels or quantum dots to improve the signal sensitivity in biosensing applications. This enables multiplexed detection of multiple biomarkers simultaneously, enhancing the diagnostic capabilities of the nanoparticles.

Drug Delivery and Targeted Therapy:

Targeted Drug Delivery: The high surface area of the carbon shell allows for the attachment of drugs, targeting ligands, or molecular probes, enabling precise drug delivery to specific tissues or cells. For example, Au-C nanoparticles can be functionalized with anticancer drugs and targeting antibodies to selectively deliver therapy to tumor cells, minimizing damage to healthy tissues. The gold core can also be used to monitor the drug delivery process using imaging techniques.

Theranostic Agents: Au-C nanoparticles can serve as theranostic agents, combining both therapeutic and diagnostic functions in a single nanoparticle. The gold core can be used for thermal ablation of cancer cells (through photothermal therapy), while the carbon shell can be used for drug delivery and biosensing.

Cancer Therapy:

Photothermal Therapy: The gold core of the nanoparticles can absorb light in the near-infrared (NIR) region and convert it into heat, enabling photothermal therapy. This method involves using Au-C nanoparticles to selectively accumulate in tumors and then applying NIR light to heat the nanoparticles, causing tumor cell destruction. The carbon shell provides additional stability and functionalization options, allowing for targeted delivery of the particles to tumor sites.

Drug Delivery and Imaging: The gold core can also be used for imaging tumor sites using X-ray or CT imaging, while the carbon shell carries therapeutic agents to the tumor. This approach can be used for multimodal cancer therapy, combining imaging, drug delivery, and photothermal therapy in one system.

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