Gold Cadmium Selenium Core Shell Nanoparticles (Au/CdSe, 99.9%, APS: 80-100nm, Metal Core/Metal Shell)

Gold Cadmium Selenium Core-Shell Nanoparticles

Applications

Biomedical Imaging and Diagnostics:

Fluorescence Imaging: Due to their bright fluorescence and size-tunable emission, Au-CdSe core-shell nanoparticles are used as fluorescent probes in cellular imaging, tissue imaging, and in vivo diagnostics. The nanoparticles can be functionalized with targeting ligands, such as antibodies or peptides, to selectively bind to specific cells or tissues, making them useful for cancer imaging, blood flow monitoring, or in vivo biosensing.

Plasmonic-Enhanced Fluorescence (PEF): The plasmonic properties of the gold core enhance the fluorescence of the CdSe shell, making these nanoparticles ideal for applications requiring high sensitivity and signal enhancement, such as multiplexed imaging or early disease detection.

Biosensing:

Surface-Enhanced Raman Scattering (SERS): The gold core of the nanoparticles can be used for SERS-based biosensing, which allows the detection of biomolecules with high sensitivity and specificity. When the nanoparticles are functionalized with specific recognition molecules (e.g., antibodies or aptamers), they can be used for early detection of diseases such as cancer or infectious diseases.

Fluorescence-based Sensing: The quantum dots in the CdSe shell provide bright and tunable fluorescence signals that can be utilized for biosensing applications. The gold core enhances these fluorescence signals, allowing for highly sensitive detection of specific molecules, such as proteins, DNA, or small molecules.

Drug Delivery and Targeted Therapy:

Targeted Drug Delivery: Au-CdSe core-shell nanoparticles can be functionalized with targeting molecules to direct drugs to specific tissues, such as tumors. The gold core can be used for magnetic targeting (in combination with an external magnetic field), while the CdSe shell can deliver luminescent signals for tracking the delivery process in real-time using optical imaging.

Theranostics: These nanoparticles can act as theranostic agents, combining diagnostic imaging (fluorescence or SERS) with therapeutic effects (e.g., photothermal therapy). The gold core can be used for photothermal treatment of cancer cells, where the nanoparticles absorb light and convert it into heat to selectively kill tumor cells.

Cancer Therapy:

Photothermal Therapy: The gold core of the nanoparticles can be utilized for photothermal therapy, where the nanoparticles absorb light and convert it into heat. This localized heating can be used to destroy cancer cells or tumors. The CdSe shell can also contribute by providing fluorescent guidance during the therapy, allowing for real-time monitoring of the treatment’s effectiveness.