Doxorubicin Hydrochloride (C27H29NO11, Purity: 99.9%)
| Doxorubicin Hydrochloride | |
| Product No | NRE-30016 |
| CAS | 25316-40-9 |
| Purity | 99.9% |
| APS | <80 nm (can be customized) |
| Formula | C27H29NO11 |
| Molecular Weight | 810.3 g/mol |
| Density | 1.6±0.1 g/cm 3 |
| Color | NA |
| Melting Point | 216 ℃ |
| Boiling Point | 2950 °C |
Doxorubicin Hydrochloride Powder
Doxorubicin hydrochloride powder is a potent anthracycline antibiotic used primarily in cancer treatment. It is well-known for its effectiveness against a variety of cancers due to its ability to interfere with DNA replication and transcription.
Cancer Treatment
Chemotherapy:
Deployment: Doxorubicin hydrochloride is a cornerstone in chemotherapy regimens for various cancers. It is used both as a single agent and in combination with other drugs.
Applications:
Breast Cancer: Often used in combination with other drugs like cyclophosphamide and 5-fluorouracil in regimens such as CAF (Cyclophosphamide, Doxorubicin, and Fluorouracil) or AC (Doxorubicin and Cyclophosphamide).
Lymphomas: Effective in treating Hodgkin’s lymphoma and non-Hodgkin’s lymphoma.
Leukemias: Used in the treatment of acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML).
Sarcomas: Includes soft tissue sarcomas and bone sarcomas like osteosarcoma.
Ovarian Cancer: Part of combination regimens for advanced ovarian cancer.
Adjuvant Therapy:
Deployment: Doxorubicin is used as adjuvant therapy to eliminate residual cancer cells after primary treatment such as surgery or radiation.
Applications: Adjuvant treatment in breast cancer and other solid tumors.
Pediatric Oncology
Treatment for Childhood Cancers:
Deployment: Doxorubicin is used in pediatric oncology for the treatment of certain childhood cancers, often as part of multi-drug regimens.
Applications:
Wilms Tumor: A common kidney cancer in children.
Neuroblastoma: A cancer that arises from nerve tissue.
Ewing’s Sarcoma: A type of bone cancer.
Combination Therapy
Synergistic Regimens:
Deployment: Doxorubicin is often combined with other chemotherapeutic agents to enhance efficacy and reduce the risk of resistance.
Applications:
R-CHOP: A combination including Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone for lymphomas.
FOLFOX or FOLFIRI: Combinations of Doxorubicin with fluorouracil, leucovorin, and oxaliplatin for colorectal cancer.
Radiotherapy Sensitization
Enhanced Efficacy:
Deployment: Doxorubicin is sometimes used in conjunction with radiation therapy to enhance the effectiveness of radiation treatment.
Applications: Treatment of tumors where radiation alone might not be sufficient.
