Polyhydroxylated fullerene (Fullerenols) / C60, -OH Functionalized
The starting material is >99% purity C60 fullerenes. C60 bearing over 40 hydroxyl groups that have higher water solubility (>50 mg/mL). These exist as monodisperse nanoparticles in water, and have a valiant polishing effect. They exhibit superior antioxidant and anti-inflammatory properties
Polyhydroxylated fullerene (Fullerenols) / C60, -OH Functionalized
| Product Name | NRE-41013 |
| CAS | 99685-96-8 |
| Purity | >90% |
| Melting Point | >280 °C |
| Morphology | Spherical |
| Flash Point | > 94 °C |
| Density | 1.6 g/cm³ at 20 °C |
| Molecular Formula | C60 |
| Molecular Weight | 720.64 g/mol |
| Form | Crystalline powder |
| Orbital energy | HOMO 6.1-6.2 eV |
| Orbital energy | UMO 4.5 eV |
| Reactivity | Non Reactive/ Non Soluble |
| Stability | Completely Stable |
| Solubility | Soluble in organic solvents |
Polyhydroxylated fullerene (Fullerenols Application
Applications:
Polyhydroxylated fullerenes are modified fullerenes where hydroxyl groups (-OH) are attached to the carbon atoms, often creating derivatives of C60 (buckminsterfullerene). These hydroxylated fullerenes, especially C60(OH)x, are of great interest in various fields due to their enhanced water solubility, biocompatibility, and antioxidant properties. Below are some of the key applications of polyhydroxylated fullerenes:
Biomedical and Therapeutic Applications
Antioxidant Properties: Polyhydroxylated fullerenes, particularly C60(OH)24, possess powerful antioxidant activity. They can effectively scavenge harmful free radicals in the body, which are implicated in aging and many diseases, including cancer, neurodegenerative disorders (e.g., Alzheimer’s and Parkinson’s), and cardiovascular diseases. These fullerenes could be used as therapeutic agents to protect cells from oxidative stress.
Drug Delivery Systems: Due to their hydrophilic nature, polyhydroxylated fullerenes are well-suited for drug delivery applications. They can serve as drug carriers, encapsulating hydrophobic drugs within their structure and improving the bioavailability of poorly soluble drugs. The modification with hydroxyl groups also enhances their ability to dissolve in water, making them better suited for in vivo applications. Fullerenes are particularly useful in delivering anticancer drugs, chemotherapeutic agents, or biological molecules like nucleic acids in gene therapy.
Gene Therapy: Polyhydroxylated fullerenes can also be used as gene delivery carriers. By attaching DNA or RNA molecules to the surface of fullerenes, they can be used to deliver genetic material to target cells, making them potential tools for gene therapy in treating genetic disorders.
Environmental Applications
Water Purification and Pollutant Removal: Polyhydroxylated fullerenes are being researched for their ability to remove contaminants from water. They can adsorb or interact with heavy metals, organic pollutants, and other toxic substances. This makes them potentially useful for water treatment and environmental remediation. They can help in the removal of pollutants like pesticides, pharmaceutical residues, and industrial chemicals from contaminated water sources.
